{"id":11,"date":"2024-08-20T20:21:00","date_gmt":"2024-08-20T20:21:00","guid":{"rendered":"https:\/\/labs.bio.cmu.edu\/kaplow\/?page_id=11"},"modified":"2026-08-10T15:40:04","modified_gmt":"2026-08-10T15:40:04","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.bio.cmu.edu\/kaplow\/","title":{"rendered":"Home"},"content":{"rendered":"<div class=\"et_pb_section_0 et_pb_section et_section_regular et_block_section\">\n<div class=\"et_pb_row_0 et_pb_row et_block_row\">\n<div class=\"et_pb_column_0 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_text_0 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h2 style=\"text-align: center;\">Welcome to<\/h2>\n<h1 style=\"text-align: center;\">the Kaplow lab!<\/h1>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_1 et_pb_section et_pb_fullwidth_section et_section_regular et_block_section\">\n<div class=\"et_pb_fullwidth_image_0 et_pb_fullwidth_image et_pb_module\" title=\"Kaplow Lab 2026\" alt=\"Kaplow Group Photo - fun image of Irene Kaplow and her lab students by the pillars of Mellon Institute\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2026\/08\/img_hero_260715_Kaplow_group-6-copy.jpg\" alt=\"four people standing\" title=\"img_kaplow_lab_group2\" width=\"2000\" height=\"1149\" srcset=\"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2026\/08\/img_hero_260715_Kaplow_group-6-copy.jpg 2000w, https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2026\/08\/img_hero_260715_Kaplow_group-6-copy-1280x735.jpg 1280w, https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2026\/08\/img_hero_260715_Kaplow_group-6-copy-980x563.jpg 980w, https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2026\/08\/img_hero_260715_Kaplow_group-6-copy-480x276.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 2000px, 100vw\" class=\"wp-image-226\" \/><\/div>\n<\/div>\n\n<div class=\"et_pb_section_2 et_pb_section et_section_regular et_block_section\">\n<div class=\"et_pb_row_1 et_pb_row et_pb_equal_columns et_block_row\">\n<div class=\"et_pb_column_1 et_pb_column et_pb_column_1_2 et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_text_1 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><p style=\"text-align: left;\">The Kaplow Lab studies vertebrate phenotype evolution by using genome comparisons to identify genetic mechanisms that are shared by distantly related species with the same phenotype. A major challenge in identifying these mechanisms is that they often involve weakly conserved enhancers\u2014non-protein coding regions that regulate when and where genes are expressed. To address this challenge, we develop approaches for identifying enhancers associated with phenotype evolution that use machine learning predictions of tissue- or cell-type-specific enhancer activity across genomes from hundreds of species paired with species' phenotype annotations. The results from our computational methods often lead to specific hypotheses about the roles of enhancers in regulating genes involved in phenotypes, and we test these hypotheses experimentally. We are currently focusing on metabolic phenotypes, such as carnivory and hibernation. We also investigate the specific mechanisms through which enhancer activity has changed between species, including the influence of changes in transcription factor binding that affect tissue-specific gene expression.<\/p>\n<\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_2 et_pb_column et_pb_column_1_2 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_image_0 et_pb_image et_pb_module et_block_module\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2024\/08\/transcriptionalRegulationVsEvolutionMouse5_liverCarniovryTacit.png\" width=\"1230\" height=\"657\" srcset=\"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2024\/08\/transcriptionalRegulationVsEvolutionMouse5_liverCarniovryTacit.png 1230w, https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2024\/08\/transcriptionalRegulationVsEvolutionMouse5_liverCarniovryTacit-980x523.png 980w, https:\/\/labs.bio.cmu.edu\/kaplow\/wp-content\/uploads\/sites\/40\/2024\/08\/transcriptionalRegulationVsEvolutionMouse5_liverCarniovryTacit-480x256.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) 1230px, 100vw\" class=\"wp-image-91\" title=\"img_transcriptionalRegulationVsEvolutionMouse5_liverCarniovryTacit\" alt=\"transcriptional regulation vs evolution mouse\" \/><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_3 et_pb_section et_section_regular et_block_section\">\n<div class=\"et_pb_row_2 et_pb_row et_pb_equal_columns et_block_row\">\n<div class=\"et_pb_column_3 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_module et_pb_button_module_wrapper et_pb_button_0_wrapper\"><a class=\"et_pb_button_0 et_pb_button et_pb_bg_layout_light et_pb_module et_block_module\" href=\"https:\/\/labs.bio.cmu.edu\/kaplow\/people\/\">Meet our Team<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/pages\/11","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":22,"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":227,"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/pages\/11\/revisions\/227"}],"wp:attachment":[{"href":"https:\/\/labs.bio.cmu.edu\/kaplow\/wp-json\/wp\/v2\/media?parent=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}