{"id":65,"date":"2013-01-20T17:47:28","date_gmt":"2013-01-20T17:47:28","guid":{"rendered":"http:\/\/www.bio.cmu.edu\/laboratories\/kuhlman\/?page_id=65"},"modified":"2020-05-01T16:43:43","modified_gmt":"2020-05-01T16:43:43","slug":"research-interests","status":"publish","type":"page","link":"https:\/\/labs.bio.cmu.edu\/kuhlman\/research-interests\/","title":{"rendered":"Research Topics"},"content":{"rendered":"<p>&nbsp;<\/p>\n<h3 style=\"text-align: center\">Impact of sensory experience on the construction of neural circuits<\/h3>\n<p>&nbsp;<\/p>\n<div id=\"attachment_122\" style=\"width: 310px\" class=\"wp-caption aligncenter\"><a title=\"Neural Circuit Assembly and Development\" href=\"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/excitatoryInhibitoryNeuronsCMUAbstract.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-122\" class=\"wp-image-122 size-medium\" src=\"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/excitatoryInhibitoryNeuronsCMUAbstract-300x202.png\" alt=\"excitatoryInhibitoryNeuronsCMUAbstract\" width=\"300\" height=\"202\" srcset=\"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/excitatoryInhibitoryNeuronsCMUAbstract-300x202.png 300w, https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/excitatoryInhibitoryNeuronsCMUAbstract-768x516.png 768w, https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/excitatoryInhibitoryNeuronsCMUAbstract-1024x688.png 1024w, https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/excitatoryInhibitoryNeuronsCMUAbstract.png 1268w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-122\" class=\"wp-caption-text\">In-vivo images of an excitatory and PV+ inhibitory neuron. Upper left images are from <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15509747\" target=\"_blank\" rel=\"noopener noreferrer\">Chattopadhyaya 2004<\/a>, fixed tissue demonstrating the &#8216;basket&#8217; surrounding excitatory soma formed by inhibitory axons.<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h3 style=\"text-align: center\">Functional impact of inhibition on cortical processing<\/h3>\n<div id=\"attachment_207\" style=\"width: 375px\" class=\"wp-caption aligncenter\"><a href=\"http:\/\/www.bio.cmu.edu\/laboratories\/kuhlman\/circuit-development\/functional-plasticity-2\/ \u200e\" rel=\"attachment wp-att-207\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-207\" class=\"wp-image-207 \" src=\"http:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/invivoRecording.png\" alt=\"invivoRecording\" width=\"365\" height=\"216\" srcset=\"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/invivoRecording.png 822w, https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/invivoRecording-300x178.png 300w, https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/invivoRecording-768x456.png 768w\" sizes=\"auto, (max-width: 365px) 100vw, 365px\" \/><\/a><p id=\"caption-attachment-207\" class=\"wp-caption-text\">2-photon guided recording of a PV+ inhibitory neuron in an awake mouse atop a spherical treadmill. Cell-attached spike response to a drifting grating stimulus is highlighted in gray.<\/p><\/div>\n<p style=\"text-align: center\"><em>\u00a0<\/em><\/p>\n<h3 style=\"text-align: center\"><\/h3>\n<h3 style=\"text-align: center\"><a title=\"Structural Plasticity\" href=\"http:\/\/www.bio.cmu.edu\/laboratories\/kuhlman\/circuit-development\/structural-plasticity\/\">Neural correlates of learning and memory<\/a><\/h3>\n<div id=\"attachment_243\" style=\"width: 248px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-243\" class=\"size-full wp-image-243 \" src=\"http:\/\/labs.bio.cmu.edu\/kuhlman\/wp-content\/uploads\/sites\/3\/2013\/01\/GoNo-Go.png\" alt=\"GoNo-Go\" width=\"238\" height=\"124\" \/><p id=\"caption-attachment-243\" class=\"wp-caption-text\">Sensory-motor\u00a0 task used to monitor structural changes in neuronal wiring during discrimination and object localization learning.\u00a0 <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20130203\" target=\"_blank\" rel=\"noopener noreferrer\">Task based on O&#8217;Connor 2010<\/a>.<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Impact of sensory experience on the construction of neural circuits &nbsp; &nbsp; &nbsp; Functional impact of inhibition on cortical processing \u00a0 Neural correlates of learning and memory &nbsp; &nbsp;<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"footnotes":""},"class_list":["post-65","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/ParKn6-13","_links":{"self":[{"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/pages\/65","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/comments?post=65"}],"version-history":[{"count":2,"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/pages\/65\/revisions"}],"predecessor-version":[{"id":457,"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/pages\/65\/revisions\/457"}],"wp:attachment":[{"href":"https:\/\/labs.bio.cmu.edu\/kuhlman\/wp-json\/wp\/v2\/media?parent=65"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}