{"id":8,"date":"2014-01-23T19:27:29","date_gmt":"2014-01-23T19:27:29","guid":{"rendered":"https:\/\/www.bio.cmu.edu\/labs\/mcmanus2\/?page_id=8"},"modified":"2026-03-23T14:15:12","modified_gmt":"2026-03-23T14:15:12","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.bio.cmu.edu\/mcmanus\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"et_pb_section_0 et_pb_section et_section_regular et_block_section\">\n<div class=\"et_pb_row_0 et_pb_row et_block_row\">\n<div class=\"et_pb_column_0 et_pb_column et_pb_column_4_4 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_image_0 et_pb_image et_pb_module et_block_module\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/cropped-logo5.gif\" width=\"1779\" height=\"408\" srcset=\"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/cropped-logo5.gif 1779w\" sizes=\"(max-width: 1779px) 100vw, 1779px\" class=\"wp-image-462\" title=\"cropped-logo5.gif\" \/><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_1 et_pb_section et_section_regular et_block_section\">\n<div class=\"et_pb_row_1 et_pb_row et_block_row\">\n<div class=\"et_pb_column_1 et_pb_column et_pb_column_2_5 et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_image_1 et_pb_image et_animated et_pb_module et_block_module\"><span class=\"et_pb_image_wrap\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/DSC00855-scaled.jpg\" width=\"1707\" height=\"2560\" srcset=\"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/DSC00855-scaled.jpg 1707w, https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/DSC00855-200x300.jpg 200w, https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/DSC00855-683x1024.jpg 683w, https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/DSC00855-768x1152.jpg 768w, https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/DSC00855-1024x1536.jpg 1024w, https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-content\/uploads\/sites\/2\/2025\/03\/DSC00855-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" class=\"wp-image-413\" title=\"DSC00855\" alt=\"group of people sitting on stairs outside of Mellon Institute\" \/><\/span><\/div>\n<\/div>\n\n<div class=\"et_pb_column_2 et_pb_column et_pb_column_3_5 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_text_0 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h1>Research Overview<\/h1>\n<\/div><\/div>\n\n<div class=\"et_pb_text_1 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><h3>How does variation in gene expression contribute to phenotypic diversity and disease?<\/h3>\n<\/div><\/div>\n\n<div class=\"et_pb_text_2 et_pb_text et_pb_bg_layout_light et_pb_module et_block_module\"><div class=\"et_pb_text_inner\"><p>Research in the McManus lab focuses on understanding mechanisms that regulate mRNA translation. Using a combination of high throughput sequencing assays and bioinformatics, we examine how variation in RNA sequences and structures can affect protein production. We are particularly interested in untranslated regions (UTRs) and how they can affect the translation of a gene. Our work spans a wide range of research interests, from human genes and genetic disorders to translation regulation in fungal pathogens.<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"et_pb_section_2 et_pb_section et_section_regular et_block_section\">\n<div class=\"et_pb_row_2 et_pb_row et_pb_equal_columns et_block_row\">\n<div class=\"et_pb_column_3 et_pb_column et_pb_column_1_3 et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_cta_0 et_pb_promo et_pb_bg_layout_dark et_animated et_clickable et_pb_module et_block_module\"><div class=\"et_pb_promo_description\"><h2 class=\"et_pb_module_header\">Upstream Open Reading Frames (uORFs)<\/h2><\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_4 et_pb_column et_pb_column_1_3 et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_cta_1 et_pb_promo et_pb_bg_layout_dark et_animated et_clickable et_pb_module et_block_module\"><div class=\"et_pb_promo_description\"><h2 class=\"et_pb_module_header\">Translation Regulation in Fungal Pathogens<\/h2><\/div><\/div>\n<\/div>\n\n<div class=\"et_pb_column_5 et_pb_column et_pb_column_1_3 et-last-child et_block_column et_pb_css_mix_blend_mode_passthrough\">\n<div class=\"et_pb_cta_2 et_pb_promo et_pb_bg_layout_dark et_animated et_clickable et_pb_module et_block_module\"><div class=\"et_pb_promo_description\"><h2 class=\"et_pb_module_header\">Prader-Willi syndrome<\/h2><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/ParKnc-8","_links":{"self":[{"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":38,"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":725,"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/pages\/8\/revisions\/725"}],"wp:attachment":[{"href":"https:\/\/labs.bio.cmu.edu\/mcmanus\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}