The Yttri Lab interrogates the functional interactions of the motor circuit that lead to behavior through several novel techniques:
- Behavioral (reaching task in a mouse, quantitative open-field locomotion, Parkinson’s disease models)
- Physiological (50, 100 and 1000 channel electrodes, blue and red shifted channel rhodopsins, closed-loop stimulation)
- Computational (dynamical systems analyses of neural population activity and machine learning-based categorization of behavior)
These methods allow us sample and manipulate the neural activity of multiple areas simultaneous in our effort to understand the mechanisms of motor behavior and movement diseases
Yttri Lab in the news:
03.01.20 – “Open-source joystick manipulandum for decision-making, reaching, and motor control studies in mice.” now in print at eNeuro, Pubmed.
02.22.20 – Eric shared what the lab is doing as one of four professors invited to speak at the CMU Board of Trustees retreat in San Francisco. The lab’s hard work made it easy to encourage the Board to think about what we as a university can “Make Possible“.
01.31.20 – Another PAPER ACCEPTED! Postdoc Matt Geramita and Prof Susanne Ahmari and I wrote a comptrehensive interesting summary of reinforcement learning, various tasks to assess it, and how we can translate findings from mouse to man. Coming soon to J Neuro Res
01.25.20 – PAPER ACCEPTED! Great work by Parley Belsey and Mark Nicholas demonstrating how to build and implement an inexpensive joystick to do reaching, reaction time, and decision-making tasks! Look for it in eNeuro soon!
01.23.20 – Thanks to Karunesh Ganguly, UCSF, for a fantastic visit to the lab and insightful talk to the Neuroscience Institute!
01.22.20 – Alex Hodge presented an excellent survey of his recent work to the CMU Research Seminar on reinforcement learning on unconstrained behavior using closed-loop stimulation of striatum. Well done!
12.15.19 – Happy Holidays from the Yttri lab!!!!!
11.18.19 – Congrats to Jean Namgoong for winning the 2020 Small Undergraduate Research Grant! Her work with optogenetic phototagging demonstrates what is possible with a good opportunity and a great undergrad!
10.02.19 – B-SOiD (“b-side”) toolbox released and getting great exposure. The software provides unbiased, unsupervised classification of naturalistic behaviors with millisecond resolution. Easy to use and applicable to mice, rats, monkeys, birds or humans! Excellent job Alex Hsu!!!
09.25.19 – Eric Yttri named to the Allen Institute’s Next Generation Leaders Council. Thankful for Christof Koch’s words: “The 2019 group is an impressive cadre of rising stars in neuroscience and we’re looking forward to the perspective they will bring to our research programs.”
07.09.19 – Congrats to Alex Hodge! He receives the College’s Graduate Student Conference Award, the only student in Biological Sciences to do so
07.04.19 – Eric’s interview, lab’s work, and creative picture made by the lab, featured in a CNN story about the science of ‘Stranger Things’
06.17.19 – Excited to announce that the Brain Research Foundation has selected our proposal to study how value decisions are made by genetically different populations of neurons across mPFC / striatal circuits!
05.24.19 – Parley Belsey wins the Elizabeth W. Jones Award for Excellence in Undergraduate Research at her graduation! Another great achievement for her. We’re excited that she’ll be coming back to the Yttri lab to carry on her excellent research!
05.08.19 – Congratulations to Parley for placing second in her group at the Sigma Xi Poster Competition at Meeting of the Minds 2019 presenting her excellent work on building an automated mouse reach task capable of two-armed bandit and reaction time tasks!
04.22.19 – Yttri Lab receives DSF Foundation Collaborative Research grant to develop high-density, flexible neural probes that fully digitize and spike sort ON THE PROBE – saving time, effort, and data bandwidth.
04.01.19 – Video of Eric’s recent fantastic talk on cortico-striatal interactions and delineating the function of the basal ganglia circuit to the Society for Neuroscience’s advisory board
03.13.19 – Latest publication! In this Biorxiv pre-print, Parley and Mark describe and benchmark our easy-to-build mouse joysticks that enable closed-loop stimulation in realtime as well as complex reaction time and probabilistic learning tasks.
03.11.19 – An article was just published summarizing our Open Science Symposium last fall, paid for in part by a grant from the DSF Foundation. The article can be found here and video of the fantastic talks can be found here
03.06.19 – RECEIVED FIRST R01,JUST 18 MONTHS SINCE STARTING THE LAB!!!!!!!!!
This grant is to create a fully customizable, 3D printed ultra high density electrode array, in collaboration with Dr Rahul Panat. This array will ultimately be used to record from thousands of neurons across several targeted brain regions to answer questions concerning neural mechanisms of action and improvement of AI transfer learning algorithms.
10.10.18 – The Yttri lab published a new review about the potential for optogenetic research to improve deep brain stimulation!
09.07.18 – Congratulations Eric Yttri for winning the Kaufman New Investigator Award. The goal of the proposal is to explore how multiple brain areas work together to learn and improve movement. More details on the award can be found here
08.15.18 – Congratulations Eric Yttri for winning the Whitehall Foundation Award. The 3 year grant will cover how cortical and basal ganglia interactions orchestrate movement and value-based decisions
05.30.18 – Congrats to the ‘Deep Nets’ team for winning the CMU Neurohackathon using our lab’s dataset of reaching / hundreds of simultaenously recorded cortical and striatal neurons!
03.07.18 – Congrats to Parley Belsey – winner of the CMU Open Science Logo Competition
Now accepting rotation students and postdocs !!!