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Big questions. Big data sets. Big results.

The Yttri lab interrogates the functional interactions of the motor circuit that lead to behavior through several novel techniques:

  • Behavioral (reaching task in a mouse, quantitative open-field locomotion, Parkinson’s disease models)
  • Physiological (50, 100 and 1000 channel electrodes, blue and red shifted channel rhodopsins, closed-loop stimulation)
  • Computational (dynamical systems analyses of neural population activity and machine learning-based categorization of behavior)

These methods allow us sample and manipulate the neural activity of multiple areas simultaneous in our effort to understand the mechanisms of motor behavior and movement diseases


Yttri Lab in the news:

11.18.19 – Congrats to Jean Namgoong for winning the 2020 Small Undergraduate Research Grant! Her work with optogenetic phototagging demonstrates what is possible with a good opportunity and a great undergrad!

10.02.19 – B-SOiD (“b-side”) toolbox released and getting great exposure. The software provides unbiased, unsupervised classification of naturalistic behaviors with millisecond resolution. Easy to use and applicable to mice, rats, monkeys, birds or humans!  Excellent job Alex Hsu!!!

09.25.19 – Eric Yttri named to the Allen Institute’s Next Generation Leaders Council. Thankful for Christof Koch’s words: “The 2019 group is an impressive cadre of rising stars in neuroscience and we’re looking forward to the perspective they will bring to our research programs.”

09.17.19 – BioRxiv preprint of fully-customizable microelectrode CMU Array is out. Also started our raffle to win an array made specifically for the winners’ experimental question!!!

09.12.19 – Getting some media attention for our recent large-scale recording grant! Here’s two stories, including a CMU feature and a 3D Printing Industry article.

07.09.19 – Congrats to Alex Hodge! He receives the College’s Graduate Student Conference Award, the only student in Biological Sciences to do so

07.04.19 – Eric’s interview, lab’s work, and creative picture made by the lab, featured in a CNN story about the science of ‘Stranger Things’
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06.17.19 – Excited to announce that the Brain Research Foundation has selected our proposal to study how value decisions are made by genetically different populations of neurons across mPFC / striatal circuits!

05.24.19 – Parley Belsey wins the Elizabeth W. Jones Award for Excellence in Undergraduate Research at her graduation! Another great achievement for her. We’re excited that she’ll be coming back to the Yttri lab to carry on her excellent research!

05.08.19 – Congratulations to Parley for placing second in her group at the Sigma Xi Poster Competition at Meeting of the Minds 2019 presenting her excellent work on building an automated mouse reach task capable of two-armed bandit and reaction time tasks!

04.22.19 – Yttri Lab receives DSF Foundation Collaborative Research grant to develop high-density, flexible neural probes that fully digitize and spike sort ON THE PROBE – saving time, effort, and data bandwidth.

04.01.19 – Video of Eric’s recent fantastic talk on cortico-striatal interactions and delineating the function of the basal ganglia circuit to the Society for Neuroscience’s advisory board

03.13.19 – Latest publication!  In this Biorxiv pre-print, Parley and Mark describe and benchmark our easy-to-build mouse joysticks that enable closed-loop stimulation in realtime as well as complex reaction time and probabilistic learning tasks.

03.11.19 – An article was just published summarizing our Open Science Symposium last fall, paid for in part by a grant from the DSF Foundation. The article can be found here and video of the fantastic talks can be found here

03.06.19 – RECEIVED FIRST R01,JUST 18 MONTHS SINCE STARTING THE LAB!!!!!!!!!
This grant is to create a fully customizable, 3D printed ultra high density electrode array, in collaboration with Dr Rahul Panat. This array will ultimately be used to record from thousands of neurons across several targeted brain regions to answer questions concerning neural mechanisms of action and improvement of AI transfer learning algorithms.

10.10.18 – The Yttri lab published a new review about the potential for optogenetic research to improve deep brain stimulation!

09.07.18 – Congratulations Eric Yttri for winning the Kaufman New Investigator Award. The goal of the proposal is to explore how multiple brain areas work together to learn and improve movement. More details on the award can be found here

08.15.18 – Congratulations Eric Yttri for winning the Whitehall Foundation Award. The 3 year grant will cover how cortical and basal ganglia interactions orchestrate movement and value-based decisions

05.30.18 – Congrats to the ‘Deep Nets’ team for winning the CMU Neurohackathon using our lab’s dataset of reaching / hundreds of simultaenously recorded cortical and striatal neurons!

04.01.18 – Just published! Summary of our quantifiable, testable model of how the motor system and basal ganlia work in health and disease states. Email us if you have any questions.

03.21.18 – Yttri lab wins DSF Young Investigator Grant and funding for Open Science Symposium

03.07.18 – Congrats to Parley Belsey – winner of the CMU Open Science Logo Competition
CMU Open Science Logo Competition

02.27.18 – Barbara Shinn-Cunningham To Lead Carnegie Mellon’s New Neuroscience Institute

08.29.17 – Introducing Assistant Professor Eric Yttri

Now accepting rotation students and postdocs  !!!