Pittsburgh RNA Community

There is a diverse and interactive community of scientists in Pittsburgh studying RNA structure, processing and function. These nine lab groups, listed below, meet together once each month. Students and postdoctoral fellows present recent research results or solicit feedback about ideas for new experiments. Each year the Pittsburgh RNA community hosts a series of outside speakers. Recent visitors have been Jennifer Doudna from Berkeley, Phil Sharp from M.I.T., Alan Hennebusch from the NIH, Thom Dever from the NIH, Rob Britton from Baylor College of Medicine, Eckhard Jankowsky from Case Western, Matt Sachs from Texas A&M, Kristian Baker from Case Western, and Kevin Weeks from University of North Carolina.

  1. At the University of Pittsburgh School of Medicine, Chris Milcarek is studying 3′ end processing of immunoglobulin mRNAs during B cell development.
  2. At the University of Pittsburgh Department of Biological Sciences, Paula Grabowski’s labstudies regulation of alternative splicing in the brain, Craig Peebles’ lab investigates the mechanism of group II intron splicing, Andrea Berman studies the structure and function of noncoding RNAs, and Andrew VanDemark uses x-ray crystallography to study structure of proteins mediates transcription and recombination.
  3. At Carnegie Mellon University, Bruce Armitage develops peptide nucleic acids as tools for study of RNA, Gordon Rule studies the structure of RNA binding proteins, including E. Coli rho factor, and Joel McManus studies regulation of alternative splicing and MRNA translation in fruit flies and yeast, Huaiying Zhang studies protein RNA phase transition, and Anna Kietrys studies chemical biology, small RNAs and circular RNAs.

Pittsburgh Yeast Community

The community of scientists in Pittsburgh who study the baker’s yeast Saccharomyces cerevisiae has diverse but complementary interests including transcription, RNA processing, and membrane trafficking. The group interacts with each other in many productive collaborations, meets together once a month where students and postdocs discuss recent research progress, and frequently share reagents and ideas.

  1. At the University of Pittsburgh, Karen Arndt studies initiation transcription focusing on the TATA binding factor TBP and interacting proteins. Jeff Brodsky studies molecular chaperones necessary for translocation of proteins into the ER. William Saunders’ lab is interested in motor proteins in the spindle necessary for mitosis or meiosis. Craig Peebles studies the mechanism of group II intron splicing in yeast. Andy VanDemark’s lab uses X-ray crystallography and other biophysical techniques to study chromatin biology-how it is packaged, remodeled, and expressed. Anthony Schwacha’s research focuses on regulation of DNA replication. Yu Jiang’s lab investigates control of yeast cell growth and proliferation in response to changing environmental conditions such as nutrient availability or stress. Allyson O’Donnell studies α-arrestins that regulate GPCR signaling. Craig Kaplan studies mechanisms of transcription. Kara Bernstein studies repair of DNA damage. Anne-Ruxandra Carvunis studies molecular mechanisms of change and innovation in biological systems.
  2. At the University of Pittsburgh School of Medicine, Martin Schmidt’s group investigates regulation of transcription via the glucose signaling pathway.


  1. Cell Press
  2. EMBO J.
  3. Genes and Development
  4. Genetics
  5. J. of Cell Biology
  6. J. of Mol. Biology
  7. Mol. Biology of the Cell
  8. Mol. and Cell. Biol.
  9. Nature
  10. Proc. Natl. Acad. Sci.
  11. RNA
  12. Science
  13. The Journal of Biological Chemistry
  14. Trends in Genetics
  15. Trends in Cell Biology
  16. Nature Structural and Molecular Biology
  17. Nature Reviews Molecular Biology
  18. Nucleic Acids Research


  1. Biotoolkit
    Advanced online tools for molecular biology data retrieval, analysis, and visualization. Annotated links to web tools for the study of nucleic acid, genome, and protein structure.
  2. DNA Sequencing Center
  3. Matrix Science
  4. RNA fold
  5. NCBI Blast
  6. NCBI Entrez
  7. Phosphobase
  8. PubMed
  9. Genewiz
  10. Protein data bank
  11. World wild protein data bank
  12. Molecular Visualization Freeware (Protein Explorer, Chime & RasMol)
  13. Rasmol and open rasmol
  14. Jmol


Ribosome meeting 2009

Yeast Resources

  1. Euroscarf
  2. Biogrid
  3. Proteome Database
    An up-to-date accumulation of knowledge on all the proteins of the yeast Saccharomyces cerevisiae and Caenorhabditis elegans. The wealth of knowledge on these proteins can be applied as a model to gain rapid insights on the cellular functions of all eukaryotic cells, from fungi to humans.
  4. Saccharomyces Genome Database
    SGD is a scientific database of the molecular biology and genetics of the yeast Saccharomyces cerevisiae, which is commonly known as baker’s or budding yeast.
  5. Tandem Affinity Purification Homepage
    New affinity tag and a purification strategy that allow efficient and reliable recovery of proteins under native conditions.
  6. Yeast Protein Database
  7. Yeast Resource Center
  8. Open Biosystems
  9. Protein complexes
  10. Restriction Enzyme Database

Ribosome Resources

  1. Nucleolar Protein Database
  2. Ribosomal Protein Tables at MIPS
  3. S. cerevisiae Ribosome Nomenclature
  4. snoRNA Database
  5. Trans-Acting Factors
  6. WD Repeats
  7. RNA helicases
  8. Noncoding RNA database

Pittsburgh City

  1. Pennsylvania State Parks
    This is the official home page of the Pennsylvania Bureau of State Parks. Begin your adventure here.
  2. Carnegie Museums of Pittsburgh
    Originally established by Andrew Carnegie in 1895, it now includes the Carnegie Museum of Art, Carnegie Museum of Natural History, Carnegie Science Center, and The Andy Warhol Museum. As one of America’s great cultural centers, Carnegie Museums of Pittsburgh serves residents of the region, as well as national and international audiences. To find out more, see the Carnegie Museums of Pittsburgh 1998 Overview.
  3. Pittsburgh Symphony Orchestra
    PSO and Heinz Hall calendar, ticket info, biographies of musicians.
  4. Phipps Conservatory and Botanical Gardens
    a thirteen-room, Victorian glasshouse and gardens featuring tropical indoor displays, seasonal flower shows, exhibits and butterflies.
  5. Local Weather
  6. CitySearch
  7. Pittsburgh’s 250th Anniversary
  8. Pittsburgh Pirates Baseball
  9. Pittsburgh Steelers Football
  10. Pittsburgh Penguins Hockey


Provide below is a list of home pages of Labs with similar biology interests:

  1. Alain Jacquier
  2. Alan Warren
  3. Angus Lamond
  4. Arlen Johnson
  5. Atlanta Cook
  6. Brenda Peculis
  7. Charles Boone
  8. Daniele Hernandez-Verdun
  9. David Schneider
  10. David Tollervey
  11. Denis Lafontaine
  12. Dieter Kressler
  13. Dimitri Pestov
  14. Ed Hurt
  15. Gloria Culver
  16. Harry F. Noller
  17. Herbert Tschochner
  18. Irene Bozzoni
  19. Ivelitza Garcia
  20. James R. Williamson
  21. Janine Maddock
  22. Jennifer Gallagher
  23. Joan Steitz
  24. Jon Warner
  25. Katrin Karbstein
  26. Mark E. Schmitt
  27. Markus Bohnsack
  28. Marlene Oeffinger
  29. Martin Kos
  30. Mike Tyers
  31. Patrick Linder
  32. Philipp Milkereit
  33. Sander Granneman
  34. Sarah Woodson
  35. Steven Ellis
  36. Susan Baserga
  37. Susan Gerbi
  38. Thoru Pederson
  39. Vikram Panse
  40. Sebastian Klinge
  41. Jesus de la Cruz
  42. Brigitte Pertschy
  43. Joaquin Ortega
  44. Robert Britton
  45. Mercedes Dosil